PNC-27 5mg

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PNC-27 is a research peptide composed of a p53–MDM2 binding domain linked to a membrane-targeting sequence (residues 12–26 of the p53 protein). It has been shown in preclinical studies to interact with cancer cell membranes through HDM-2–associated mechanisms, leading to selective pore formation and membrane destabilization. PNC-27 is utilized in experimental oncology research to investigate peptide–membrane interactions, apoptotic signaling, and tumor-selective cytolytic activity in vitro.

For research use only. Not for human consumption.

References:
Sotomayor EM et al., Int J Cancer, 2005 115(5):701–709
Arora V et al., J Cell Biochem, 2013 114(3):664–671
Hu W et al., Oncotarget, 2017 8(29):47425–47436

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OVERVIEW

PNC-27 5mg is a synthetic peptide derived from a segment of the p53 tumor suppressor protein, combined with a membrane-penetrating sequence that allows it to enter cells. It has been studied primarily in laboratory and preclinical research for its potential ability to selectively target cancer cells. The proposed mechanism involves binding to HDM-2 (human double minute 2), a protein often overexpressed in certain tumor cells. By interacting with this pathway, PNC-27 has been observed in experimental settings to induce cancer cell membrane disruption while sparing healthy cells, though this effect has mainly been demonstrated in vitro.

At a 5mg dosage, PNC-27 is generally supplied for research purposes only and is not approved by major regulatory authorities for clinical or therapeutic use. Most available data come from laboratory and animal studies, and comprehensive human clinical trials are lacking. While early findings have generated scientific interest, questions remain regarding safety, delivery methods, dosing protocols, and long-term effects in humans. Because PNC-27 interacts with critical cellular regulatory pathways associated with tumor biology, its use outside controlled research environments is not recommended. Anyone exploring information about experimental peptides should consult qualified medical and research professionals for accurate, up-to-date guidance.

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