GHRP-6 (5mg x 10), CJC-1295 no DAC (5mg x 10)

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GHRP-6 and CJC-1295 no DAC (Mod GRF 1-29) are synthetic research peptides commonly used together in experimental models to investigate growth hormone axis regulation and pituitary signaling mechanisms. GHRP-6 is a hexapeptide growth hormone secretagogue that binds the growth hormone secretagogue receptor (GHS-R1a), activating Gq/PLC-dependent calcium signaling pathways involved in GH release. CJC-1295 no DAC is a stabilized analog of growth hormone–releasing hormone (GHRH 1-29) that activates the GHRH receptor, stimulating adenylate cyclase and cAMP-mediated signaling. Preclinical studies demonstrate that combined GHS-R1a agonists and GHRH analogs are used to study synergistic somatotropic signaling, hypothalamic–pituitary feedback, and peptide-mediated endocrine regulation.

For research use only. Not for human consumption.

References:
Frohman LA et al., Endocr Rev, 2001 22(6):606–648
Bowers CY et al., Ann NY Acad Sci, 1998 865:244–249
Smith RG et al., Science, 1997 275(5304):1261–1264

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OVERVIEW

GHRP-6 (5 mg × 10) and CJC-1295 no DAC (5 mg × 10) is a peptide combination commonly used in research to stimulate growth hormone (GH) release. GHRP-6 is a growth hormone-releasing peptide (GHRP) that acts by binding to the ghrelin receptor (GHS-R1a), triggering the release of GH from the pituitary gland. One of its key effects is increasing insulin-like growth factor-1 (IGF-1), which plays a role in promoting muscle growth, tissue repair, and fat metabolism. CJC-1295 no DAC, a synthetic growth hormone-releasing hormone (GHRH) analog, also stimulates GH release but does so via the GHRH receptor. Unlike CJC-1295 with DAC (Drug Affinity Complex), the no DAC variant has a shorter half-life, promoting more natural, pulsatile GH secretion. The combination of these two peptides enhances GH release through two distinct pathways: one via ghrelin receptor activation (GHRP-6) and the other through GHRH receptor activation (CJC-1295 no DAC), making it a popular blend in research studies focused on metabolic function, recovery, and regenerative medicine.

Despite its research applications, this peptide combination is not FDA-approved for therapeutic use in humans. Most data supporting its biological effects comes from animal studies, in vitro experiments, and small human trials, while safety, dosing, and long-term effects in humans remain poorly understood. Products containing these peptides are often labeled for research use only and may vary in purity, concentration, and quality. Individuals interested in GH modulation or metabolic research should rely on evidence-based treatments and consult healthcare professionals before using experimental peptides outside of controlled research environments.

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